Do calcimimetics directly alter bone remodeling?

Do calcimimetics directly alter bone remodeling?

SECONDARY HYPERPARATHYROIDISM is an almost inevitable consequence of untreated chronic kidney disease (CKD), resulting in disordered skeletal remodeling and mineralization defects. Thus, due to the high circulating levels of parathyroid hormone (PTH), both osteoblast and osteoclast surfaces may be augmented and ultimately bone volume may be reduced (11). In CKD, synthesis of 1,25 dihydroxyvitam...

Do corticosteroids really alter mood?

FSH Directly Regulates Bone Mass

Postmenopausal osteoporosis, a global public health problem, has for decades been attributed solely to declining estrogen levels. Although FSH levels rise sharply in parallel, a direct effect of FSH on the skeleton has never been explored. We show that FSH is required for hypogonadal bone loss. Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism. Bone ma...

Bone Remodeling and Healing

To fulfill adequately their functions of support, sustentation and protection for the internal organs and guarantee blood calcium homeostasis, bone tissue is in constant remodeling. Alveolar bone, the primary support structure for teeth, is particularly subjected to continuous and fast remodeling associated with tooth eruption and positional adaptations, as well as with the functional demands o...

normAl bone remodelIng

Paget’s disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased os...